- Early Intrahepatic Recurrence of Hepatocellular Carcinoma with Metastasis to Lung and Brain after Radiofrequency Ablation
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Jin Dong Kim, Jung Hyun Kwon, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Young Jun Lee, Sung Eun Rha, Ho Jong Chun, Byung Gil Choi, Hae Giu Lee
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Journal of the Korean Liver Cancer Study Group. 2009;9(1):37-40. Published online June 30, 2009
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- Radiofrequency ablation (RFA) is the preferred method of local ablation for patients with small (<3 cm sized)
hepatocellular carcinoma (HCC) when surgical resection cannot be applied. If RFA procedure is sufficiently completed, it
provides lower local tumor recurrence, and longer overall as well as disease-free survival. We experienced a case of early
stage HCC which recurred at 2 months after successful RFA procedure, and rapidly metastasized to lung and brain.
- Rapid recurrence following living donor liver transplantation for hepatocellular carcinoma within Milan criteria
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Hyun Young Woo, Jin Dong Kim, Jung Hyun Kwon, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Sung Eun Rha, Jae Young Byun, Ho Jong Chun, Byung Gil Choi, Hae Kyu Lee, Young Kyoung You, Dong Gu Kim
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Journal of the Korean Liver Cancer Study Group. 2009;9(1):45-48. Published online June 30, 2009
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- Liver transplantation is curative therapy for hepatocellular carcinoma especially if ,within Milan criteria, 4 year survival
and recurrence-free survival was reported to be 85% and 92%, respectively. Herein we report a patient who experience rapid
recurrence following living donor liver transplantation (LDLT) for hepatocellular carcinoma within Milan criteria. A 52
year-old-men patient with known liver cirrhosis associated with hepatitis B virus was admitted for the treatment of
hepatocellular carcinoma (HCC). Abdominal CT revealed two nodules less than 3 cm in right hepatic lobe. After single
session of transcatheter arterial chemoembolization (TACE), the patient underwent LDLT. After seven months following
transplantation, recurrent HCC was detected on transplanted liver with concurrent metastatic nodule in lung. Although TACE
and metastsectomy were performed for recurrent intrahepatic mass and lung metastasis, recurrent HCC showed rapid
progression and patient died of progressive tumor after 10 months following LDLT.
- A Case of Advanced Hepatocellular Carcinoma in Twenties Treated by Multimodality Therapy
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Jang Eun Lee, Na Ri Yoon, Si Hyun Bae, Jong Young Choi, Seung Kew Yoon, Dong Goo Kim, Ho Jong Chun, Byung Gil Choi, Hae Giu Lee, Hong Seok Jang, Chan Kwon Jung, Eun Sun Jang
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Journal of the Korean Liver Cancer Study Group. 2009;9(1):82-85. Published online June 30, 2009
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- The prognosis of young patients with hepatocellular carcinoma is remains controversial. Here we report a case of advanced
hepatocellular carcinoma in twenty, successfully treated with transarterial chemolipidolization (TACL), systemic chemotherapy,
radiation therapy and surgical resection. Previously healthy 28 years old woman was admitted for treatment of hepatocellular
carcinoma. Abdominal CT showed a diffuse infiltrative HCC involving both lobes with intrahepatic bile duct invasion and
pericardial lymphadenopathy. She was treated TAC with systemic chemotherapy and external beam radiotherapy. 6 months
after these treatments, main tumor and the pericardial lymph node were decreased in size. And then extended left lobectomy
and systemic chemotherapy were done. The pericardial lymph node was markedly decreased. The patient has been followed
for 10 months without evidence of regional tumor recurrence.
- A Case of Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis Achieving Complete Response with New Therapeutic Modalities
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Hyun Young Woo, Jin Dong Kim, Jung Hyun Kwon, Chan Ran You, Jeong Won Jang, Si Hyun Bae, Jong Young Choi, Se Hyun Cho, Seung Kew Yoon, Dong Hoon Lee, Ho Jong Chun, Byung Gil Choi, Chul Seung Kay
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Journal of the Korean Liver Cancer Study Group. 2008;8(1):124-127. Published online June 30, 2008
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Abstract
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- A 45-year-old man was admitted for the treatment of hepatocellular carcinoma (HCC). He was diagnosed
hepatitis B carrier 16 years ago and has not done a routine check. Abdominal CT showed a diffuse infiltrative
HCC involving right hepatic lobe with portal vein tumor thrombosis (PVTT) involving right portal vein and
proximal portion of left portal vein umbilical portion. With concurrent transcatheter arterial chemotherapy (TAC),
helical tomotherapy for portal vein thrombosis was done. With these treatments, main tumor and PVTT was
decreased in size markedly and no stain in hepatic angiogram. Due to repeated TAC, hepatic arterial stenosis
occurred and TAC was stopped. 3 months after, recurrent tumor was detected in MRI. Radiofrequency ablation
followed by High Intensity Focused Ultrasound (HIFU) was done for this recurrent mass. No viable mass was
shown in the follow up MRI done 6 months after HIFU.
- Combined hepatocellular and cholangiocarcinoma
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Jung Hyun Kwon, Si Hyun Bae, Jung Pil Suh, Ho Sung Park, Chan Ran You, Jong Young Choi, Seung Kew Yoon, Dong Hoon Lee, Ho Jong Chun, Byung Gil Choi, Chan Kwon Chung, Eun Sun Jung, Mi Ryung Ryu
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Journal of the Korean Liver Cancer Study Group. 2007;7(1):49-54. Published online June 30, 2007
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- A 43 year-old-women patient was admitted for one month of jaundice. She was diagnosed hepatitis B carrier
17 years ago and has not done a routine check. Abdominal CT showed a large ill defined mass in left hepatic lobe
with inhomogenous enhancement in arterial and delayed phase. The result of biopsy including the
immunohistochemical stains showed the combined hepatocellular and cholangiocarcinoma (stage IVa, type C by
Allen and Lisa). With the radiation therapy (3,910 cGy), six times of transarterial chemo-lipiodolization and two
times of percutaneous ethanol injection, huge mass was markedly decreased in size and no stain in hepatic
angiogram. She underwent left lobectomy.
- A Case of Cyberknife Treatment for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis
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Chan Ran You, Si Hyun Bae, Hyun Young Woo, Soung Won Jeong, Jong Young Choi, Seung Kew Yoon, Hong Seok Jang, Dong Hoon Lee, Byung Gil Choi
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Journal of the Korean Liver Cancer Study Group. 2007;7(1):82-86. Published online June 30, 2007
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- A 64 year-old-male patient was transferred to our hospital for infiltrative hepatocellular carcinoma (HCC)
without treatment response because of treatment failure and disease progression. He had been diagnosed
infiltrating HCC 9 months ago and then treated with three times of transarterial chemolipiodolization (TACL) in
other hospital. But, HCC was progressed. Abdominal CT showed infiltrating HCC in S7 and a small daughter
nodule in S8 with right and main portal vein tumor thrombosis (PVTT). We performed stereotatic radiosurgery
(Cyberknife) for the treatment of PVTT and four times of TACL for the treatment of intrahepatic HCC every
4weeks. The total radiation doses using with Cyberknife were 36Gy with a prescription isodose 80% in 3 fractions
over the three consecutive days. After treatment, infiltrating HCC was decreased in size and PVTT was markedly
regressed. Response rate of serum AFP was 57.2%. In conclusion, we report the case of good treatment response
in the patient with HCC with PVTT after combination treatment of Cyberknife and TACL.
- A Case of Advanced Hepatocellular Carcinoma : Curative Resection after Repeated Transcatheter Arterial Chemoembolization, Systemic Chemotherapy and Radiotherapy
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So Yeon Lee, Seung Kew Yoon, Min Su Kim, Si Hyun Bae, Jong Young Choi, Byung Gil Choi, Ho Jong Chun, Dong Gu Kim, Seok Whan Moon
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Journal of the Korean Liver Cancer Study Group. 2006;6(1):38-41. Published online June 30, 2006
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Abstract
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- A 46 year-old male patient was admitted to our hospital for evaluation of hepatic mass which was detected on
ultrasonography. He had a history of chronic hepatitis B carrier. Laboratory findings showed that HBsAg was
positive, and HBeAg was negative. AFP was 2,081.1 ng/mL. Abdomen CT showed a large well-defined low
density lesion involving entire right hepatic lobe which was compatable with advanced hepatocellular carcinoma
(stage III). Celiac and hepatic arteriogram reveled huge hypervascular mass at both lobe of the liver.
Transcatheter arterial chemoembolization (TACE), systemic chemotherapy, percutaneous ethanol injection therapy
(PEIT), and radiotherapy were combined as the treatment of huge hepatoma. After combined therapy, tumor
decreased in size. As a result, curative right lobectomy could be performed. Six months after surgery, chest CT
showed two small metastatic nodules in both lung, so wedge resection was performed. We followed the patient
for 5 years after operation and there was no evidence of regional tumor recurrence or distant metastasis.
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